Well, I think you are dead on with thinking its informant (since the error is titled "Informant") but as to the why... It depends on what the app does. Check to see if you have any other applications open that might be putting a strain on Informant.
Thanks Hawk, I'll look with that said I have informant set to sync on launch only. The other day it kept firing this message about every 30 seconds while on my way to Sacramento I had to park and delete the app and noticed the phone was way hot, after deletion everything was normal, guess I better email the Dev.