If your NES emulator becomes extremely slow when you try to switch on sound, and/or doesn't produce any noise once enabled, you will have to force quit the program to get sound working again.
To force quit, hold the Home button until you see the NES application switch out to the springboard. This takes roughly 5 seconds.
To force quit, hold the Home button until you see the NES application switch out to the springboard. This takes roughly 5 seconds.